alefacept

Ligand id: 6787

Name: alefacept

References
1. da Silva AJ, Brickelmaier M, Majeau GR, Li Z, Su L, Hsu YM, Hochman PS. (2002)
Alefacept, an immunomodulatory recombinant LFA-3/IgG1 fusion protein, induces CD16 signaling and CD2/CD16-dependent apoptosis of CD2(+) cells.
J. Immunol.168 (9): 4462-71. [PMID:11970990]
2. Miller GT, Hochman PS, Meier W, Tizard R, Bixler SA, Rosa MD, Wallner BP. (1993)
Specific interaction of lymphocyte function-associated antigen 3 with CD2 can inhibit T cell responses.
J. Exp. Med.178 (1): 211-22. [PMID:7686212]
3. Mitchell P. (2002)
First biotech drug to treat psoriasis.
Nat. Biotechnol.20 (7): 640-1. [PMID:12089534]