clofarabine

Ligand id: 6802

Name: clofarabine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 3
Rotatable bonds 2
Topological polar surface area 119.31
Molecular weight 303.05
XLogP -0.55
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Parker WB, Shaddix SC, Chang CH, White EL, Rose LM, Brockman RW, Shortnacy AT, Montgomery JA, Secrist 3rd JA, Bennett Jr LL. (1991)
Effects of 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine on K562 cellular metabolism and the inhibition of human ribonucleotide reductase and DNA polymerases by its 5'-triphosphate.
Cancer Res.51 (9): 2386-94. [PMID:1707752]