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Compound class:
Peptide or derivative
Comment: Synthetic analogue of angiotensin-II
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
| References |
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1. Holloway AC, Qian H, Pipolo L, Ziogas J, Miura S, Karnik S, Southwell BR, Lew MJ, Thomas WG. (2002)
Side-chain substitutions within angiotensin II reveal different requirements for signaling, internalization, and phosphorylation of type 1A angiotensin receptors. Mol Pharmacol, 61 (4): 768-77. [PMID:11901215] |
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2. Miura S, Feng YH, Husain A, Karnik SS. (1999)
Role of aromaticity of agonist switches of angiotensin II in the activation of the AT1 receptor. J Biol Chem, 274 (11): 7103-10. [PMID:10066768] |
