bapineuzumab

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Ligands
bapineuzumab

GtoPdb Ligand ID: 6930

Synonyms: 3D-6 | AAB-001

Comment: Humanized monoclonal antibody to amyloid β (Aβ). Binds to Aβ deposits and reduces amyloid load primarily through microglial clearance.

References
1. Miles LA, Crespi GA, Doughty L, Parker MW. (2013) Bapineuzumab captures the N-terminus of the Alzheimer's disease amyloid-beta peptide in a helical conformation. Sci Rep, 3: 1302. [PMID:23416764]
2. Roher AE, Cribbs DH, Kim RC, Maarouf CL, Whiteside CM, Kokjohn TA, Daugs ID, Head E, Liebsack C, Serrano G et al.. (2013) Bapineuzumab alters aβ composition: implications for the amyloid cascade hypothesis and anti-amyloid immunotherapy. PLoS ONE, 8 (3): e59735. [PMID:23555764]
3. Salloway S, Sperling R, Fox NC, Blennow K, Klunk W, Raskind M, Sabbagh M, Honig LS, Porsteinsson AP, Ferris S et al.. (2014) Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease. N Engl J Med, 370 (4): 322-33. [PMID:24450891]

References

1. Miles LA, Crespi GA, Doughty L, Parker MW. (2013)
Bapineuzumab captures the N-terminus of the Alzheimer's disease amyloid-beta peptide in a helical conformation.
Sci Rep, 3: 1302. [PMID:23416764]

2. Roher AE, Cribbs DH, Kim RC, Maarouf CL, Whiteside CM, Kokjohn TA, Daugs ID, Head E, Liebsack C, Serrano G et al.. (2013)
Bapineuzumab alters aβ composition: implications for the amyloid cascade hypothesis and anti-amyloid immunotherapy.
PLoS ONE, 8 (3): e59735. [PMID:23555764]

3. Salloway S, Sperling R, Fox NC, Blennow K, Klunk W, Raskind M, Sabbagh M, Honig LS, Porsteinsson AP, Ferris S et al.. (2014)
Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease.
N Engl J Med, 370 (4): 322-33. [PMID:24450891]