AZ-4217

Ligand id: 6939

Name: AZ-4217

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 71.58
Molecular weight 476.2
XLogP 6.08
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

References
1. Eketjäll S, Janson J, Jeppsson F, Svanhagen A, Kolmodin K, Gustavsson S, Radesäter AC, Eliason K, Briem S, Appelkvist P et al.. (2013)
AZ-4217: a high potency BACE inhibitor displaying acute central efficacy in different in vivo models and reduced amyloid deposition in Tg2576 mice.
J. Neurosci.33 (24): 10075-84. [PMID:23761903]