begacestat

Ligand id: 6979

Name: begacestat

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 103.02
Molecular weight 390.95
XLogP 3.1
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Martone RL, Zhou H, Atchison K, Comery T, Xu JZ, Huang X, Gong X, Jin M, Kreft A, Harrison B et al.. (2009)
Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.
J. Pharmacol. Exp. Ther.331 (2): 598-608. [PMID:19671883]