Ligand Id: 723
Ligand name L-glutamine

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 3
Rotatable bonds 4
Topological polar surface area 106.41
Molecular weight 146.07
XLogP -4.08
No. Lipinski's rules broken 0

Molecular properties generated using the CDK


Summary Biological activity References Structure Similar ligands Radio analogues
References
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Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids.
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2. Hatanaka, T; Huang, W; Wang, H; Sugawara, M; Prasad, PD; Leibach, FH; Ganapathy, V. (2000)
Primary structure, functional characteristics and tissue expression pattern of human ATA2, a subtype of amino acid transport system A.
Biochim. Biophys. Acta1467 (1): 1-6. [PMID:10930503]
3. Nakanishi, T; Sugawara, M; Huang, W; Martindale, RG; Leibach, FH; Ganapathy, ME; Prasad, PD; Ganapathy, V. (2001)
Structure, function, and tissue expression pattern of human SN2, a subtype of the amino acid transport system N.
Biochem. Biophys. Res. Commun.281 (5): 1343-8. [PMID:11243884]
4. Hatanaka, T; Huang, W; Ling, R; Prasad, PD; Sugawara, M; Leibach, FH; Ganapathy, V. (2001)
Evidence for the transport of neutral as well as cationic amino acids by ATA3, a novel and liver-specific subtype of amino acid transport system A.
Biochim. Biophys. Acta1510 (1-2): 10-7. [PMID:11342143]
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Na+ transport by the neural glutamine transporter ATA1.
Pflugers Arch.443 (1): 92-101. [PMID:11692272]
6. Zaia, KA; Reimer, RJ. (2009)
Synaptic Vesicle Protein NTT4/XT1 (SLC6A17) Catalyzes Na+-coupled Neutral Amino Acid Transport.
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7. Vanslambrouck, JM; Bröer, A; Thavyogarajah, T; Holst, J; Bailey, CG; Bröer, S; Rasko, JE. (2010)
Renal imino acid and glycine transport system ontogeny and involvement in developmental iminoglycinuria.
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Primary structure, genomic organization, and functional and electrogenic characteristics of human system N 1, a Na+- and H+-coupled glutamine transporter.
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9. Hägglund, MG; Sreedharan, S; Nilsson, VC; Shaik, JH; Almkvist, IM; Bäcklin, S; Wrange, O; Fredriksson, R. (2011)
Identification of SLC38A7 (SNAT7) protein as a glutamine transporter expressed in neurons.
J. Biol. Chem.286 (23): 20500-11. [PMID:21511949]