piroxicam

Ligand id: 7273

Name: piroxicam

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 111.47
Molecular weight 331.06
XLogP 3.66
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Lazer ES, Miao CK, Cywin CL, Sorcek R, Wong HC, Meng Z, Potocki I, Hoermann M, Snow RJ, Tschantz MA et al.. (1997)
Effect of structural modification of enol-carboxamide-type nonsteroidal antiinflammatory drugs on COX-2/COX-1 selectivity.
J. Med. Chem.40 (6): 980-9. [PMID:9083488]
2. Wilkerson WW, Copeland RA, Covington M, Trzaskos JM. (1995)
Antiinflammatory 4,5-diarylpyrroles. 2. Activity as a function of cyclooxygenase-2 inhibition.
J. Med. Chem.38 (20): 3895-901. [PMID:7562922]