etazolate

Ligand id: 7336

Name: etazolate

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 81.4
Molecular weight 289.15
XLogP 2.33
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Marcade M, Bourdin J, Loiseau N, Peillon H, Rayer A, Drouin D, Schweighoffer F, Désiré L. (2008)
Etazolate, a neuroprotective drug linking GABA(A) receptor pharmacology to amyloid precursor protein processing.
J. Neurochem.106 (1): 392-404. [PMID:18397369]
2. Vellas B, Sol O, Snyder PJ, Ousset PJ, Haddad R, Maurin M, Lemarié JC, Désiré L, Pando MP, EHT0202/002 study group. (2011)
EHT0202 in Alzheimer's disease: a 3-month, randomized, placebo-controlled, double-blind study.
Curr Alzheimer Res8 (2): 203-12. [PMID:21222604]
3. Zezula J, Slany A, Sieghart W. (1996)
Interaction of allosteric ligands with GABAA receptors containing one, two, or three different subunits.
Eur. J. Pharmacol.301 (1-3): 207-14. [PMID:8773466]