panobinostat

Ligand id: 7489

Name: panobinostat

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: panobinostat

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 4
Rotatable bonds 8
Topological polar surface area 77.15
Molecular weight 349.18
XLogP 4.71
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Khan N, Jeffers M, Kumar S, Hackett C, Boldog F, Khramtsov N, Qian X, Mills E, Berghs SC, Carey N et al.. (2008)
Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors.
Biochem. J.409 (2): 581-9. [PMID:17868033]
2. Mack GS. (2010)
To selectivity and beyond.
Nat. Biotechnol.28 (12): 1259-66. [PMID:21139608]