pirfenidone

Ligand id: 7532

Name: pirfenidone

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 1
Topological polar surface area 20.31
Molecular weight 185.08
XLogP 3.34
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Conte E, Gili E, Fagone E, Fruciano M, Iemmolo M, Vancheri C. (2014)
Effect of pirfenidone on proliferation, TGF-β-induced myofibroblast differentiation and fibrogenic activity of primary human lung fibroblasts.
Eur J Pharm Sci58: 13-9. [PMID:24613900]
2. García L, Hernández I, Sandoval A, Salazar A, Garcia J, Vera J, Grijalva G, Muriel P, Margolin S, Armendariz-Borunda J. (2002)
Pirfenidone effectively reverses experimental liver fibrosis.
J. Hepatol.37 (6): 797-805. [PMID:12445421]
3. King Jr TE, Bradford WZ, Castro-Bernardini S, Fagan EA, Glaspole I, Glassberg MK, Gorina E, Hopkins PM, Kardatzke D, Lancaster L et al.. (2014)
A phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis.
N. Engl. J. Med.370 (22): 2083-92. [PMID:24836312]
4. Macías-Barragán J, Sandoval-Rodríguez A, Navarro-Partida J, Armendáriz-Borunda J. (2010)
The multifaceted role of pirfenidone and its novel targets.
Fibrogenesis Tissue Repair3: 16. [PMID:20809935]