Ligand id: 7556

Name: perospirone

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 0
Rotatable bonds 6
Topological polar surface area 84.99
Molecular weight 426.21
XLogP 3.23
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Seeman P, Chau-Wong M, Tedesco J, Wong K. (1975)
Brain receptors for antipsychotic drugs and dopamine: direct binding assays.
Proc. Natl. Acad. Sci. U.S.A., 72: 4376-4380. [PMID:1060115]
2. Seeman P, Tallerico T. (1998)
Antipsychotic drugs which elicit little or no parkinsonism bind more loosely than dopamine to brain D2 receptors, yet occupy high levels of these receptors.
Mol. Psychiatry, 3 (2): 123-34. [PMID:9577836]
3. Sokoloff P, Andrieux M, Besançon R, Pilon C, Martres M-P, Giros B, Schwartz J-C. (1992)
Pharmacology of human D3 dopamine receptor expressed in a mammalian cell line : comparison with D2 receptor.
Eur. J. Pharmacol., 225: 331-337. [PMID:1354163]