ASP-3026

Ligand id: 7740

Name: ASP-3026

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 10
Hydrogen bond donors 2
Rotatable bonds 9
Topological polar surface area 124.2
Molecular weight 580.29
XLogP 4.23
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. George SK, Vishwamitra D, Manshouri R, Shi P, Amin HM. (2014)
The ALK inhibitor ASP3026 eradicates NPM-ALK⁺ T-cell anaplastic large-cell lymphoma in vitro and in a systemic xenograft lymphoma model.
Oncotarget5 (14): 5750-63. [PMID:25026277]
2. Mori M, Ueno Y, Konagai S, Fushiki H, Shimada I, Kondoh Y, Saito R, Mori K, Shindou N, Soga T et al.. (2014)
The selective anaplastic lymphoma receptor tyrosine kinase inhibitor ASP3026 induces tumor regression and prolongs survival in non-small cell lung cancer model mice.
Mol. Cancer Ther.13 (2): 329-40. [PMID:24419060]