AZ4800

Ligand id: 7805

Name: AZ4800

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 83.32
Molecular weight 435.23
XLogP 3.24
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Borgegard T, Juréus A, Olsson F, Rosqvist S, Sabirsh A, Rotticci D, Paulsen K, Klintenberg R, Yan H, Waldman M et al.. (2012)
First and second generation γ-secretase modulators (GSMs) modulate amyloid-β (Aβ) peptide production through different mechanisms.
J. Biol. Chem.287 (15): 11810-9. [PMID:22334705]
2. Strömberg K, Eketjäll S, Georgievska B, Tunblad K, Eliason K, Olsson F, Radesäter AC, Klintenberg R, Arvidsson PI, von Berg S et al.. (2014)
Combining an amyloid-beta (Aβ) cleaving enzyme inhibitor with a γ-secretase modulator results in an additive reduction of Aβ production.
FEBS J.,  [Epub ahead of print]. [PMID:25303711]