AZD7687

Ligand id: 7827

Name: AZD7687

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 106.17
Molecular weight 367.19
XLogP 4.85
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Barlind JG, Bauer UA, Birch AM, Birtles S, Buckett LK, Butlin RJ, Davies RD, Eriksson JW, Hammond CD, Hovland R et al.. (2012)
Design and optimization of pyrazinecarboxamide-based inhibitors of diacylglycerol acyltransferase 1 (DGAT1) leading to a clinical candidate dimethylpyrazinecarboxamide phenylcyclohexylacetic acid (AZD7687).
J. Med. Chem.55 (23): 10610-29. [PMID:23116186]