example 20 [WO2010128058]

Ligand id: 7853

Name: example 20 [WO2010128058]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 113.57
Molecular weight 372.11
XLogP 0.71
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Banner D et.al. (2010)
Dihydropyrimidinones for use as BACE2 inhibitors.
Patent number: WO2010128058. Assignee: Roche. Priority date: 31/10/2014. Publication date: 11/11/2010.
2. Southan C. (2013)
BACE2 as a new diabetes target: a patent review (2010 - 2012).
Expert Opin Ther Pat23 (5): 649-63. [PMID:23506624]