Synonyms: AHU377 | Entresto® | Neparvis®
sacubitril is an approved drug (EMA & FDA (2015))
Compound class:
Synthetic organic
Comment: Sacubitril is a prodrug activated by de-ethylation via esterases to the neprilysin inhibitor sacubitrilat. Neprilysin is also known as neutral endopeptidase (NEP), and its official gene symbol is MME (membrane metallo-endopeptidase ). The chemical database relationships are detailed in this blogpost. Sabucatril is a component of the approved fixed mixture Entresto®, previously known as LCZ696, and which is now approved for heart failure (see Clinical data tab).
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References |
1. McMurray JJ, Packer M, Desai AS, Gong J, Lefkowitz MP, Rizkala AR, Rouleau JL, Shi VC, Solomon SD, Swedberg K et al.. (2014)
Angiotensin-neprilysin inhibition versus enalapril in heart failure. N Engl J Med, 371 (11): 993-1004. [PMID:25176015] |