crenolanib

Ligand id: 7882

Name: crenolanib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 78.43
Molecular weight 443.23
XLogP 3.93
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Heinrich MC, Griffith D, McKinley A, Patterson J, Presnell A, Ramachandran A, Debiec-Rychter M. (2012)
Crenolanib inhibits the drug-resistant PDGFRA D842V mutation associated with imatinib-resistant gastrointestinal stromal tumors.
Clin. Cancer Res.18 (16): 4375-84. [PMID:22745105]