BGT-226

Ligand id: 7951

Name: BGT-226

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 73.83
Molecular weight 534.2
XLogP 4.6
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Markman B, Tabernero J, Krop I, Shapiro GI, Siu L, Chen LC, Mita M, Melendez Cuero M, Stutvoet S, Birle D et al.. (2012)
Phase I safety, pharmacokinetic, and pharmacodynamic study of the oral phosphatidylinositol-3-kinase and mTOR inhibitor BGT226 in patients with advanced solid tumors.
Ann. Oncol.23 (9): 2399-408. [PMID:22357447]