1-azakenpaullone

Ligand id: 8018

Name: 1-azakenpaullone

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 0
Topological polar surface area 57.78
Molecular weight 327
XLogP 2.57
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Cai Z, Zhao Y, Zhao B. (2012)
Roles of glycogen synthase kinase 3 in Alzheimer's disease.
Curr Alzheimer Res9 (7): 864-79. [PMID:22272620]
2. Eldar-Finkelman H, Schreyer SA, Shinohara MM, LeBoeuf RC, Krebs EG. (1999)
Increased glycogen synthase kinase-3 activity in diabetes- and obesity-prone C57BL/6J mice.
Diabetes48 (8): 1662-6. [PMID:10426388]
3. Hurtado DE, Molina-Porcel L, Carroll JC, Macdonald C, Aboagye AK, Trojanowski JQ, Lee VM. (2012)
Selectively silencing GSK-3 isoforms reduces plaques and tangles in mouse models of Alzheimer's disease.
J. Neurosci.32 (21): 7392-402. [PMID:22623685]
4. Kunick C, Lauenroth K, Leost M, Meijer L, Lemcke T. (2004)
1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta.
Bioorg. Med. Chem. Lett.14 (2): 413-6. [PMID:14698171]
5. Nikoulina SE, Ciaraldi TP, Mudaliar S, Mohideen P, Carter L, Henry RR. (2000)
Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes.
Diabetes49 (2): 263-71. [PMID:10868943]
6. Takashima A, Noguchi K, Sato K, Hoshino T, Imahori K. (1993)
Tau protein kinase I is essential for amyloid beta-protein-induced neurotoxicity.
Proc. Natl. Acad. Sci. U.S.A.90 (16): 7789-93. [PMID:8356085]