Synonyms: AZD 3409 | AZD-3409
Compound class:
Synthetic organic
Comment: AZD3409 is an an orally active double prodrug, peptidomimetic type farnesyltransferase inhibitor (FTI). It is a double prodrug in that it has its thiol and carboxylate groups blocked to reduce toxicity.
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References |
1. Appels NM, Bolijn MJ, van Eijndhoven MA, Stephens TC, Beijnen JH, Schellens JH. (2011)
Characterization of the in vitro activity of AZD3409, a novel prenyl transferase inhibitor. Cancer Chemother Pharmacol, 67 (1): 137-45. [PMID:20229082] |
2. Downward J. (2003)
Targeting RAS signalling pathways in cancer therapy. Nat Rev Cancer, 3 (1): 11-22. [PMID:12509763] |
3. Streeper R, Campos D, Carrizales G, Stephens TC, Izbicka E. (2006)
Regulation of tumor signaling pathways by AZD3409 in vitro. Anticancer Res, 26 (6B): 4185-9. [PMID:17201131] |