Compound class:
Synthetic organic
Comment: LB42708 is a highly potent, selective, and non-peptidic farnesyltransferase inhibitor (FTI). It has a similar chemical structure to LB42908.
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References |
1. Downward J. (2003)
Targeting RAS signalling pathways in cancer therapy. Nat Rev Cancer, 3 (1): 11-22. [PMID:12509763] |
2. Kim CK, Choi YK, Lee H, Ha KS, Won MH, Kwon YG, Kim YM. (2010)
The farnesyltransferase inhibitor LB42708 suppresses vascular endothelial growth factor-induced angiogenesis by inhibiting ras-dependent mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt signal pathways. Mol Pharmacol, 78 (1): 142-50. [PMID:20406854] |
3. Kim HS, Kim JW, Gang J, Wen J, Koh SS, Koh JS, Chung HH, Song SY. (2006)
The farnesyltransferase inhibitor, LB42708, inhibits growth and induces apoptosis irreversibly in H-ras and K-ras-transformed rat intestinal epithelial cells. Toxicol Appl Pharmacol, 215 (3): 317-29. [PMID:16712893] |