Synonyms: 1-methyl-D-tryptophan | 1MT | D-1MT
Compound class:
Synthetic organic
Comment: Indoximod is being investigated for its inhibitory action towards indoleamine 2,3-dioxygenase 1 (IDO1), a L-tryptophan degrading enzyme.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Ball HJ, Yuasa HJ, Austin CJ, Weiser S, Hunt NH. (2009)
Indoleamine 2,3-dioxygenase-2; a new enzyme in the kynurenine pathway. Int J Biochem Cell Biol, 41 (3): 467-71. [PMID:18282734] |
2. Fatokun AA, Hunt NH, Ball HJ. (2013)
Indoleamine 2,3-dioxygenase 2 (IDO2) and the kynurenine pathway: characteristics and potential roles in health and disease. Amino Acids, 45 (6): 1319-29. [PMID:24105077] |
3. Meininger D, Zalameda L, Liu Y, Stepan LP, Borges L, McCarter JD, Sutherland CL. (2011)
Purification and kinetic characterization of human indoleamine 2,3-dioxygenases 1 and 2 (IDO1 and IDO2) and discovery of selective IDO1 inhibitors. Biochim Biophys Acta, 1814 (12): 1947-54. [PMID:21835273] |
4. Metz R, Duhadaway JB, Kamasani U, Laury-Kleintop L, Muller AJ, Prendergast GC. (2007)
Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indoleamine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan. Cancer Res, 67 (15): 7082-7. [PMID:17671174] |
5. Metz R, Smith C, DuHadaway JB, Chandler P, Baban B, Merlo LM, Pigott E, Keough MP, Rust S, Mellor AL et al.. (2014)
IDO2 is critical for IDO1-mediated T-cell regulation and exerts a non-redundant function in inflammation. Int Immunol, 26 (7): 357-67. [PMID:24402311] |