avosentan

Ligand id: 8260

Name: avosentan

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 8
Topological polar surface area 133.8
Molecular weight 479.13
XLogP 3.36
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Breu, V. et al.. (2003)
Heterocyclic sulfonamides.
Patent number: US6521631. Assignee: Hoffmann-La Roche. Priority date: 13/03/2015. Publication date: 18/02/2003.
2. Mann JF, Green D, Jamerson K, Ruilope LM, Kuranoff SJ, Littke T, Viberti G, ASCEND Study Group. (2010)
Avosentan for overt diabetic nephropathy.
J. Am. Soc. Nephrol.21 (3): 527-35. [PMID:20167702]