Synonyms: Aezea® (proposed proprietary name) | EL625
Compound class:
Synthetic organic
Comment: Cenersen is a 20mer phosphorothioate antisense oligonucleotide complementary to a region of p53 messenger RNA [1]. The oligonucleotide sequence is reported as 5′-d[P-Thio](ccctgctccc ccctggctcc)-3′ [1]. This sequence matches nucleotides 1273-1292 of RefSeq nucleotide NM_000546 (Homo sapiens tumor protein p53 (TP53), transcript variant 1, mRNA).
|
References |
1. Alachkar H, Xie Z, Marcucci G, Chan KK. (2012)
Determination of cellular uptake and intracellular levels of Cenersen (Aezea(®), EL625), a p53 antisense oligonucleotide in acute myeloid leukemia cells. J Pharm Biomed Anal, 71: 228-32. [PMID:22944355] |