Ligand id: 8274

Name: mifamurtide

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View more information in the IUPHAR Pharmacology Education Project: mifamurtide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 25
Hydrogen bond donors 10
Rotatable bonds 59
Topological polar surface area 385.91
Molecular weight 1236.75
XLogP 9.69
No. Lipinski's rules broken 4

Molecular properties generated using the CDK

1. Anderson PM, Tomaras M, McConnell K. (2010)
Mifamurtide in osteosarcoma--a practical review.
Drugs Today, 46 (5): 327-37. [PMID:20517534]
2. Ando K, Mori K, Corradini N, Redini F, Heymann D. (2011)
Mifamurtide for the treatment of nonmetastatic osteosarcoma.
Expert Opin Pharmacother, 12 (2): 285-92. [PMID:21226638]
3. Kim TH, Park JH, Park YM, Ryu SW, Shin SJ, Park JH, Kim DJ. (2015)
Synergistic effect of muramyl dipeptide with heat shock protein 70 from Mycobacterium tuberculosis on immune activation.
Immunobiology, 220 (1): 26-31. [PMID:25446399]
4. Meyer T, Fabbro D, Eppenberger U, Matter A. (1986)
The lipophilic muramyltripeptide MTP-PE, a biological response modifier, is an activator of protein kinase C.
Biochem. Biophys. Res. Commun., 140 (3): 1043-50. [PMID:3465326]
5. Meyers PA, Chou AJ. (2014)
Muramyl tripeptide-phosphatidyl ethanolamine encapsulated in liposomes (L-MTP-PE) in the treatment of osteosarcoma.
Adv. Exp. Med. Biol., 804: 307-21. [PMID:24924182]
6. Murray JL, Kleinerman ES, Cunningham JE, Tatom JR, Andrejcio K, Lepe-Zuniga J, Lamki LM, Rosenblum MG, Frost H, Gutterman JU et al.. (1989)
Phase I trial of liposomal muramyl tripeptide phosphatidylethanolamine in cancer patients.
J. Clin. Oncol., 7 (12): 1915-25. [PMID:2479721]
7. Pahl JH, Kwappenberg KM, Varypataki EM, Santos SJ, Kuijjer ML, Mohamed S, Wijnen JT, van Tol MJ, Cleton-Jansen AM, Egeler RM et al.. (2014)
Macrophages inhibit human osteosarcoma cell growth after activation with the bacterial cell wall derivative liposomal muramyl tripeptide in combination with interferon-γ.
J. Exp. Clin. Cancer Res., 33: 27. [PMID:24612598]
8. Vavricka SR, Musch MW, Chang JE, Nakagawa Y, Phanvijhitsiri K, Waypa TS, Merlin D, Schneewind O, Chang EB. (2004)
hPepT1 transports muramyl dipeptide, activating NF-kappaB and stimulating IL-8 secretion in human colonic Caco2/bbe cells.
Gastroenterology, 127 (5): 1401-9. [PMID:15521010]
9. Viswanathan VK. (2014)
Muramyl dipeptide: Not just another brick in the wall.
Gut Microbes, 5 (3): 275-6. [PMID:25068259]