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Synonyms: anti-factor D | FCFD4514S | RG7417
Compound class:
Antibody
Comment: Lampalizumab is the Fab antigen binding domain of a humanized monoclonal antibody targeting complement factor D (CFD), the rate-limiting initiator of the alternative complement pathway (AP). The humanized antibody was produced based on a mouse monoclonal (MAb 166-32) [3,5].
Peptide sequences for this antibody are available from its IMGT/mAb-DB record. 
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
| References |
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1. Charbel Issa P, Chong NV, Scholl HP. (2011)
The significance of the complement system for the pathogenesis of age-related macular degeneration - current evidence and translation into clinical application. Graefes Arch Clin Exp Ophthalmol, 249 (2): 163-74. [PMID:21127893] |
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2. Do DV, Pieramici DJ, van Lookeren Campagne M, Beres T, Friesenhahn M, Zhang Y, Strauss EC, Phase Ia Investigators. (2014)
A phase ia dose-escalation study of the anti-factor D monoclonal antibody fragment FCFD4514S in patients with geographic atrophy. Retina (Philadelphia, PA), 34 (2): 313-20. [PMID:23842100] |
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3. Fung M, Loubser PG, Undar A, Mueller M, Sun C, Sun WN, Vaughn WK, Fraser Jr CD. (2001)
Inhibition of complement, neutrophil, and platelet activation by an anti-factor D monoclonal antibody in simulated cardiopulmonary bypass circuits. J Thorac Cardiovasc Surg, 122 (1): 113-22. [PMID:11436043] |
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4. Loyet KM, Good J, Davancaze T, Sturgeon L, Wang X, Yang J, Le KN, Wong M, Hass PE, Campagne Mv et al.. (2014)
Complement inhibition in cynomolgus monkeys by anti-factor d antigen-binding fragment for the treatment of an advanced form of dry age-related macular degeneration. J Pharmacol Exp Ther, 351 (3): 527-37. [PMID:25232192] |
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5. Tanhehco EJ, Kilgore KS, Liff DA, Murphy KL, Fung MS, Sun WN, Sun C, Lucchesi BR. (1999)
The anti-factor D antibody, MAb 166-32, inhibits the alternative pathway of the human complement system. Transplant Proc, 31 (5): 2168-71. [PMID:10456004] |
