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Compound class:
Peptide or derivative
Comment: A synthetic analogue of human relaxin-3 comprising a synthetic truncated from of the A chain, and a B chain matching the natural sequence of relaxin-3 B chain. The sequence of the A chain can be found from the link on the structure tab of this ligand page, and please see the ligand entry for relaxin-3 (B chain) for the sequence of the B chain. N.B. The truncated A chain subunit of this peptide is also a subunit of minimised relaxin-3 analogue 3.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
| References |
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1. de Ávila C, Chometton S, Lenglos C, Calvez J, Gundlach AL, Timofeeva E. (2018)
Differential effects of relaxin-3 and a selective relaxin-3 receptor agonist on food and water intake and hypothalamic neuronal activity in rats. Behav Brain Res, 336: 135-144. [PMID:28864207] |
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2. Praveen P, Bathgate RAD, Hossain MA. (2019)
Engineering of chimeric peptides as antagonists for the G protein-coupled receptor, RXFP4. Sci Rep, 9 (1): 17828. [PMID:31780677] |
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3. Shabanpoor F, Akhter Hossain M, Ryan PJ, Belgi A, Layfield S, Kocan M, Zhang S, Samuel CS, Gundlach AL, Bathgate RA et al.. (2012)
Minimization of human relaxin-3 leading to high-affinity analogues with increased selectivity for relaxin-family peptide 3 receptor (RXFP3) over RXFP1. J Med Chem, 55 (4): 1671-81. [PMID:22257012] |
