DZNep

Ligand id: 8392

Name: DZNep

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 4
Rotatable bonds 2
Topological polar surface area 117.42
Molecular weight 264.12
XLogP -0.77
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Glazer RI, Hartman KD, Knode MC, Richard MM, Chiang PK, Tseng CK, Marquez VE. (1986)
3-Deazaneplanocin: a new and potent inhibitor of S-adenosylhomocysteine hydrolase and its effects on human promyelocytic leukemia cell line HL-60.
Biochem. Biophys. Res. Commun.135 (2): 688-94. [PMID:3457563]
2. Tan J, Yang X, Zhuang L, Jiang X, Chen W, Lee PL, Karuturi RK, Tan PB, Liu ET, Yu Q. (2007)
Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells.
Genes Dev.21 (9): 1050-63. [PMID:17437993]