mithramycin

Ligand id: 8394

Name: mithramycin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 21
Hydrogen bond donors 11
Rotatable bonds 15
Topological polar surface area 358.2
Molecular weight 1084.47
XLogP -1.61
No. Lipinski's rules broken 3

Molecular properties generated using the CDK

References
1. BROWN JH, KENNEDY BJ. (1965)
MITHRAMYCIN IN THE TREATMENT OF DISSEMINATED TESTICULAR NEOPLASMS.
N. Engl. J. Med.272: 111-8. [PMID:14224214]
2. Jones Jr DE, Cui DM, Miller DM. (1995)
Expression of beta-galactosidase under the control of the human c-myc promoter in transgenic mice is inhibited by mithramycin.
Oncogene10 (12): 2323-30. [PMID:7784080]
3. Lin RK, Hsu CH, Wang YC. (2007)
Mithramycin A inhibits DNA methyltransferase and metastasis potential of lung cancer cells.
Anticancer Drugs18 (10): 1157-64. [PMID:17893516]
4. Rodriguez-Paredes M, Martinez de Paz A, Simó-Riudalbas L, Sayols S, Moutinho C, Moran S, Villanueva A, Vázquez-Cedeira M, Lazo PA, Carneiro F et al.. (2014)
Gene amplification of the histone methyltransferase SETDB1 contributes to human lung tumorigenesis.
Oncogene33 (21): 2807-13. [PMID:23770855]
5. Ryu H, Lee J, Hagerty SW, Soh BY, McAlpin SE, Cormier KA, Smith KM, Ferrante RJ. (2006)
ESET/SETDB1 gene expression and histone H3 (K9) trimethylation in Huntington's disease.
Proc. Natl. Acad. Sci. U.S.A.103 (50): 19176-81. [PMID:17142323]