elubirixin

Ligand id: 8499

Name: elubirixin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 4
Rotatable bonds 6
Topological polar surface area 119.15
Molecular weight 462.03
XLogP 2.61
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Bachelerie F, Ben-Baruch A, Burkhardt AM, Combadiere C, Farber JM, Graham GJ, Horuk R, Sparre-Ulrich AH, Locati M, Luster AD et al.. (2014)
International Union of Pharmacology. LXXXIX. Update on the extended family of chemokine receptors and introducing a new nomenclature for atypical chemokine receptors.
Pharmacol. Rev.66 (1): 1-79. [PMID:24218476]
2. Lazaar AL, Sweeney LE, MacDonald AJ, Alexis NE, Chen C, Tal-Singer R. (2011)
SB-656933, a novel CXCR2 selective antagonist, inhibits ex vivo neutrophil activation and ozone-induced airway inflammation in humans.
Br J Clin Pharmacol72 (2): 282-93. [PMID:21426372]
3. Moss RB, Mistry SJ, Konstan MW, Pilewski JM, Kerem E, Tal-Singer R, Lazaar AL, CF2110399 Investigators. (2013)
Safety and early treatment effects of the CXCR2 antagonist SB-656933 in patients with cystic fibrosis.
J. Cyst. Fibros.12 (3): 241-8. [PMID:22995323]