AZD8186

Ligand id: 8527

Name: AZD8186

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 71.11
Molecular weight 457.18
XLogP 2.64
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Hancox U, Cosulich S, Hanson L, Trigwell C, Lenaghan C, Ellston R, Dry H, Crafter C, Barlaam B, Fitzek M et al.. (2015)
Inhibition of PI3Kβ signaling with AZD8186 inhibits growth of PTEN-deficient breast and prostate tumors alone and in combination with docetaxel.
Mol. Cancer Ther.14 (1): 48-58. [PMID:25398829]