|
Synonyms: 6Ckine-Leu | Exodus-2
Compound class:
Endogenous peptide in human, mouse or rat
Comment: Ccl21b is a mouse CC chemokine with no human homolog. It is orthologous to human CCL21. This protein has leucine at position 65 [4].
Species: Mouse
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
| References |
|
1. Mori S, Nakano H, Aritomi K, Wang CR, Gunn MD, Kakiuchi T. (2001)
Mice lacking expression of the chemokines CCL21-ser and CCL19 (plt mice) demonstrate delayed but enhanced T cell immune responses. J Exp Med, 193 (2): 207-18. [PMID:11148224] |
|
2. Ott TR, Lio FM, Olshefski D, Liu XJ, Ling N, Struthers RS. (2006)
The N-terminal domain of CCL21 reconstitutes high affinity binding, G protein activation, and chemotactic activity, to the C-terminal domain of CCL19. Biochem Biophys Res Commun, 348 (3): 1089-93. [PMID:16904643] |
|
3. Sullivan SK, McGrath DA, Grigoriadis D, Bacon KB. (1999)
Pharmacological and signaling analysis of human chemokine receptor CCR-7 stably expressed in HEK-293 cells: high-affinity binding of recombinant ligands MIP-3beta and SLC stimulates multiple signaling cascades. Biochem Biophys Res Commun, 263: 685-690. [PMID:10512740] |
|
4. Vassileva G, Soto H, Zlotnik A, Nakano H, Kakiuchi T, Hedrick JA, Lira SA. (1999)
The reduced expression of 6Ckine in the plt mouse results from the deletion of one of two 6Ckine genes. J Exp Med, 190 (8): 1183-8. [PMID:10523616] |
