Ligand Id: 878
Ligand name L-364718

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 77.56
Molecular weight 408.16
XLogP 6.4
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Summary Biological activity References Structure Similar ligands Radio analogues
References
1. Hughes, J., Boden, P., Costall, B., Domeney, A., Kelly, E., Horwell, D. C., Hunter, J. C., Pinnock, R. D. and Woodruff, G. N. (1990)
Development of a class of selective cholecystokinin type B receptor antagonists having potent anxiolytic activity.
Proc Natl Acad Sci U S A, 87: 6728-6732. [PMID:1975695]
2. Lee, Y. M., Beinborn, M., McBride, E. W., Lu, M., Kolakowski, L. F. and Kopin, A. S. (1993)
The human brain cholecystokinin-B/gastrin receptor. Cloning and characterization.
J Biol Chem, 268: 8164-8169. [PMID:7681836]