(S)-liquiritigenin   Click here for help

GtoPdb Ligand ID: 8899

PDB Ligand Immunopharmacology Ligand
Compound class: Natural product or derivative
Comment: Liquiritigenin is a bioactive natural flavonoid present in the root of Glycyrrhizae uralensis Fisch (a type of Chinese liquorice) [3]. We show the structure with (2S) stereochemistry.
The compound has reports of anticancer and anti-inflammatory actions, of providing protection from renal and hepatic injury [1-3], and behaving as a selective estrogen receptor β agonist [3]. The tissue-protective effects appear to center on activation of nuclear erythroid 2-related factor 2 (NRF2) signalling that induces expression of antioxidant enzymes [4,6].
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 1
Topological polar surface area 66.76
Molecular weight 256.25
XLogP 0.87
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES C1=C(C=CC(=C1)O)[C@@H]2CC(=O)C3=CC=C(C=C3O2)O
Isomeric SMILES C1[C@H](OC2=C(C1=O)C=CC(=C2)O)C3=CC=C(C=C3)O
InChI InChI=1S/C15H12O4/c16-10-3-1-9(2-4-10)14-8-13(18)12-6-5-11(17)7-15(12)19-14/h1-7,14,16-17H,8H2/t14-/m0/s1
InChI Key FURUXTVZLHCCNA-AWEZNQCLSA-N
References
1. Huang Z, Zhao Q, Chen M, Zhang J, Ji L. (2019)
Liquiritigenin and liquiritin alleviated monocrotaline-induced hepatic sinusoidal obstruction syndrome via inhibiting HSP60-induced inflammatory injury.
Toxicology, 428: 152307. [PMID:31589899]
2. Lee EH, Park KI, Kim KY, Lee JH, Jang EJ, Ku SK, Kim SC, Suk HY, Park JY, Baek SY et al.. (2019)
Liquiritigenin inhibits hepatic fibrogenesis and TGF-β1/Smad with Hippo/YAP signal.
Phytomedicine, 62: 152780. [PMID:31121384]
3. Mersereau JE, Levy N, Staub RE, Baggett S, Zogovic T, Zogric T, Chow S, Ricke WA, Tagliaferri M, Cohen I et al.. (2008)
Liquiritigenin is a plant-derived highly selective estrogen receptor beta agonist.
Mol Cell Endocrinol, 283 (1-2): 49-57. [PMID:18177995]
4. Shi M, Zhang J, Li M, Zhao Y, Guo Y, Xu J, Liu R, Li Z, Ren D, Liu P. (2023)
Liquiritigenin Confers Liver Protection by Enhancing NRF2 Signaling through Both Canonical and Non-canonical Signaling Pathways.
J Med Chem, Epub ahead of print. DOI: 10.1021/acs.jmedchem.3c00815
5. Straub I, Krügel U, Mohr F, Teichert J, Rizun O, Konrad M, Oberwinkler J, Schaefer M. (2013)
Flavanones that selectively inhibit TRPM3 attenuate thermal nociception in vivo.
Mol Pharmacol, 84 (5): 736-50. [PMID:24006495]
6. Zhou M, Dai Y, Ma Y, Yan Y, Hua M, Gao Q, Geng X, Zhou Q. (2022)
Protective Effects of Liquiritigenin against Cisplatin-Induced Nephrotoxicity via NRF2/SIRT3-Mediated Improvement of Mitochondrial Function.
Molecules, 27 (12). [PMID:35744945]