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Synonyms: CDX-011 | CR011-vcMMAE
Compound class:
Antibody
Comment: Glembatumumab vedotin is a fully human anti-gpNMB (transmembrane glycoprotein NMB; gene symbol GPNMB) monoclonal antibody-drug conjugate (ADC) carrying the antineoplastic toxin monomethyl auristatin E (MMAE; PubChem CID 11542188). Development and preclinical evaluation of this ADC is reported in [4].
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record. |
| References |
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1. Kuan CT, Wakiya K, Dowell JM, Herndon 2nd JE, Reardon DA, Graner MW, Riggins GJ, Wikstrand CJ, Bigner DD. (2006)
Glycoprotein nonmetastatic melanoma protein B, a potential molecular therapeutic target in patients with glioblastoma multiforme. Clin Cancer Res, 12 (7 Pt 1): 1970-82. [PMID:16609006] |
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2. Rose AA, Grosset AA, Dong Z, Russo C, Macdonald PA, Bertos NR, St-Pierre Y, Simantov R, Hallett M, Park M et al.. (2010)
Glycoprotein nonmetastatic B is an independent prognostic indicator of recurrence and a novel therapeutic target in breast cancer. Clin Cancer Res, 16 (7): 2147-56. [PMID:20215530] |
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3. Rose AA, Pepin F, Russo C, Abou Khalil JE, Hallett M, Siegel PM. (2007)
Osteoactivin promotes breast cancer metastasis to bone. Mol Cancer Res, 5 (10): 1001-14. [PMID:17951401] |
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4. Tse KF, Jeffers M, Pollack VA, McCabe DA, Shadish ML, Khramtsov NV, Hackett CS, Shenoy SG, Kuang B, Boldog FL et al.. (2006)
CR011, a fully human monoclonal antibody-auristatin E conjugate, for the treatment of melanoma. Clin Cancer Res, 12 (4): 1373-82. [PMID:16489096] |
