Synonyms: compound 2d [PMID: 22974325] | PF 04995274 | PF04995274
Compound class:
Synthetic organic
Comment: PF-04995274 is a serotonin 5-HT4 receptor partial agonist, developed as a potential pro-cognitive agent for the treatment of Alzheimer's disease (AD) [1].
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Brodney MA, Johnson DE, Sawant-Basak A, Coffman KJ, Drummond EM, Hudson EL, Fisher KE, Noguchi H, Waizumi N, McDowell LL et al.. (2012)
Identification of multiple 5-HT₄ partial agonist clinical candidates for the treatment of Alzheimer's disease. J Med Chem, 55 (21): 9240-54. [PMID:22974325] |
2. Duwuri S, Nicholas T, Leurent C, Raunig D, Plotka A, Schwam E, Grimwood S, Rowinski C, Rapp TL.
Modulation of soluble APPα in brain by PF-04995274, a 5HT4 partial agonist, following single oral doses in healthy human volunteers: Study design and PK-PD analysis. Accessed on 07/03/2016. Modified on 07/03/2016. Alzheimers and Dementia: the Journal of the Alzheimer's Association., http://www.alzheimersanddementia.com/article/S1552-5260%2812%2900910-7/abstract. DOI: 10.1016/j.jalz.2012.05.778 |