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Compound class:
Peptide or derivative
Comment: JMR-132 is a peptidic GHRH analogue [1]. The structure is reported as PhAc0,D-Arg2,Phe(4-Cl)6,Ala8,Har9,Tyr(Me)10,His11,Abu15,His20,Nle27,D-Arg28,Har29] human GHRH (1-29)-NH2 (Abu is -aminobutyric acid, Har is homoarginine, Nle is norleucine, PhAc is phenylacetyl, and Tyr(Me) is O-methyltyrosine.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
| References |
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1. Buchholz S, Schally AV, Engel JB, Hohla F, Heinrich E, Koester F, Varga JL, Halmos G. (2007)
Potentiation of mammary cancer inhibition by combination of antagonists of growth hormone-releasing hormone with docetaxel. Proc Natl Acad Sci USA, 104 (6): 1943-6. [PMID:17261802] |
