Synonyms: BAY 1238097 | BAY-1238097
Compound class:
Synthetic organic
Comment: BAY1238097 is a BET inhibitor [1,3]. BET inhibitors bind to the bromodomains of the bromodomain and extra-terminal motif (BET) proteins BRD2, BRD3, BRD4, and BRDT. This mechanism acts to prevent protein-protein interaction between BET proteins and acetylated histones and transcription factors. The action disrupts chromatin remodeling and inhibits expression of some growth-promoting genes which slows proliferation in susceptible tumours.
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References |
1. Gelato KA, Schöckel L, Klingbeil O, Rückert T, Lesche R, Toedling J, Kalfon E, Héroult M, Lejeune P, Mönning U et al.. (2018)
Super-enhancers define a proliferative PGC-1α-expressing melanoma subgroup sensitive to BET inhibition. Oncogene, 37 (4): 512-521. [PMID:28991225] |
2. Lejeune P et al..
Abstract 3524: BAY 1238097, a novel BET inhibitor with strong efficacy in hematological tumor models. Accessed on 18/04/2016. Modified on 18/04/2016. http://cancerres.aacrjournals.org, http://cancerres.aacrjournals.org/content/75/15_Supplement/3524 |
3. Postel-Vinay S, Herbschleb K, Massard C, Woodcock V, Soria JC, Walter AO, Ewerton F, Poelman M, Benson N, Ocker M et al.. (2019)
First-in-human phase I study of the bromodomain and extraterminal motif inhibitor BAY 1238097: emerging pharmacokinetic/pharmacodynamic relationship and early termination due to unexpected toxicity. Eur J Cancer, 109: 103-110. [PMID:30711772] |