Synonyms: (2R,6R)HNK
Compound class:
Synthetic organic
Comment: A recent (April 2016) report [1] shows that the metabolism of racemic ketamine to hydroxynorketamine (HNK) is essential for its antidepressant effects, and that these reside in this entry as the (2R,6R)-HNK enantiomer. In mice these actions are independent of NMDAR inhibition and lack ketamine-related side effects. The (flat) rendering of HNK is PubChem CID 133669. The (2S,6S)-HNK is represented as PubChem CID 71519584 but this showed a decreased antidepressant effect compared to (2R,6R)-HNK.
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References |
1. Zanos P, Moaddel R, Morris PJ, Georgiou P, Fischell J, Elmer GI, Alkondon M, Yuan P, Pribut HJ, Singh NS et al.. (2016)
NMDAR inhibition-independent antidepressant actions of ketamine metabolites. Nature, 533 (7604): 481-6. [PMID:27144355] |