Compound class:
Synthetic organic
Comment: The discovery of the so-called STING agonist G10 by high throughput in vitro screening is reported in [1]. However, the authors could find no evidence of direct G10 binding to STING, despite experiments showing it being essential for the antiviral effects of the compound. The identity of the protein or factor engaged by G10 which stimulates the STING-dependent response is still being investigated.
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References |
1. Sali TM, Pryke KM, Abraham J, Liu A, Archer I, Broeckel R, Staverosky JA, Smith JL, Al-Shammari A, Amsler L et al.. (2015)
Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses. PLoS Pathog, 11 (12): e1005324. [PMID:26646986] |