CGI560

Ligand id: 9264

Name: CGI560

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 71.32
Molecular weight 461.22
XLogP 8.92
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

References
1. Di Paolo JA, Huang T, Balazs M, Barbosa J, Barck KH, Bravo BJ, Carano RA, Darrow J, Davies DR, DeForge LE et al.. (2011)
Specific Btk inhibition suppresses B cell- and myeloid cell-mediated arthritis.
Nat. Chem. Biol.7 (1): 41-50. [PMID:21113169]
2. Lou Y, Owens TD, Kuglstatter A, Kondru RK, Goldstein DM. (2012)
Bruton's tyrosine kinase inhibitors: approaches to potent and selective inhibition, preclinical and clinical evaluation for inflammatory diseases and B cell malignancies.
J. Med. Chem.55 (10): 4539-50. [PMID:22394077]