AZ191

Ligand id: 9268

Name: AZ191

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 71.34
Molecular weight 429.23
XLogP 2.09
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Ashford AL, Oxley D, Kettle J, Hudson K, Guichard S, Cook SJ, Lochhead PA. (2014)
A novel DYRK1B inhibitor AZ191 demonstrates that DYRK1B acts independently of GSK3β to phosphorylate cyclin D1 at Thr(286), not Thr(288).
Biochem. J.457 (1): 43-56. [PMID:24134204]
2. Kettle JG, Ballard P, Bardelle C, Cockerill M, Colclough N, Critchlow SE, Debreczeni J, Fairley G, Fillery S, Graham MA et al.. (2015)
Discovery and optimization of a novel series of Dyrk1B kinase inhibitors to explore a MEK resistance hypothesis.
J. Med. Chem.58 (6): 2834-44. [PMID:25738750]