EPZ011989

Ligand id: 9273

Name: EPZ011989

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 2
Rotatable bonds 12
Topological polar surface area 86.38
Molecular weight 605.39
XLogP 4.15
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

References
1. Campbell JE, Kuntz KW, Knutson SK, Warholic NM, Keilhack H, Wigle TJ, Raimondi A, Klaus CR, Rioux N, Yokoi A et al.. (2015)
EPZ011989, A Potent, Orally-Available EZH2 Inhibitor with Robust in Vivo Activity.
ACS Med Chem Lett6 (5): 491-5. [PMID:26005520]