U-47700   Click here for help

GtoPdb Ligand ID: 9282

Synonyms: compound 1 [PMID: 2999404]
Compound class: Synthetic organic
Comment: U-47700 is a selective μ-opioid receptor agonist [2], with in vivo effects similar to other potent opioid agonists (analgesia, sedation, euphoria, constipation and respiratory depression). Illicit use and fatalities caused by U-47700 [1,3-4] has prompted action to schedule the compound or make it illegal in some jurisdictions.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 23.55
Molecular weight 328.11
XLogP 3.96
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CN(C1CCCCC1N(C(=O)c1ccc(c(c1)Cl)Cl)C)C
Isomeric SMILES CN([C@@H]1CCCC[C@H]1N(C(=O)c1ccc(c(c1)Cl)Cl)C)C
InChI InChI=1S/C16H22Cl2N2O/c1-19(2)14-6-4-5-7-15(14)20(3)16(21)11-8-9-12(17)13(18)10-11/h8-10,14-15H,4-7H2,1-3H3/t14-,15-/m1/s1
InChI Key JGPNMZWFVRQNGU-HUUCEWRRSA-N
References
1. Armenian P, Olson A, Anaya A, Kurtz A, Ruegner R, Gerona RR. (2017)
Fentanyl and a Novel Synthetic Opioid U-47700 Masquerading as Street "Norco" in Central California: A Case Report.
Ann Emerg Med, 69 (1): 87-90. [PMID:27473610]
2. Cheney BV, Szmuszkovicz J, Lahti RA, Zichi DA. (1985)
Factors affecting binding of trans-N-[2-(methylamino)cyclohexyl]benzamides at the primary morphine receptor.
J Med Chem, 28 (12): 1853-64. [PMID:2999404]
3. Domanski K, Kleinschmidt KC, Schulte JM, Fleming S, Frazee C, Menendez A, Tavakoli K. (2017)
Two cases of intoxication with new synthetic opioid, U-47700.
Clin Toxicol (Phila), 55 (1): 46-50. [PMID:27432224]
4. Elliott SP, Brandt SD, Smith C. (2016)
The first reported fatality associated with the synthetic opioid 3,4-dichloro-N-[2-(dimethylamino)cyclohexyl]-N-methylbenzamide (U-47700) and implications for forensic analysis.
Drug Test Anal, 8 (8): 875-9. [PMID:27232154]