lutikizumab

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lutikizumab

GtoPdb Ligand ID: 9297

Synonyms: ABT-981 | E26.13-SS-X3 [6]

Comment: Lutikizumab (ABT-981) is an investigational monoclonal antibody targeting IL-1α and IL-1β [6], designed using proprietary technology to create dual variable domain antibodies ('DVD-Ig^TM') [3]. DVD-Igs are single pharmaceutical agents capable of simultaneously targeting two mediators of disease. The unique feature of DVD-Igs is that each arm of the antibody contains two tandem variable domains, each capable of binding a different antigen (see Figure 2 in [6]).
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.

References
1. Dayer JM, Graham R, Russell G, Krane SM. (1977) Collagenase production by rheumatoid synovial cells: stimulation by a human lymphocyte factor. Science, 195 (4274): 181-3. [PMID:188134]
2. Dayer JM, Roelke MS, Krane SM. (1984) Effects of prostaglandin E2, indomethacin, trifluoperazine and drugs affecting the cytoskeleton on collagenase production by cultured adherent rheumatoid synovial cells. Biochem Pharmacol, 33 (18): 2893-9. [PMID:6089839]
3. DiGiammarino E, Ghayur T, Liu J. (2012) Design and generation of DVD-Ig™ molecules for dual-specific targeting. Methods Mol Biol, 899: 145-56. [PMID:22735951]
4. Goldring MB, Birkhead J, Sandell LJ, Kimura T, Krane SM. (1988) Interleukin 1 suppresses expression of cartilage-specific types II and IX collagens and increases types I and III collagens in human chondrocytes. J Clin Invest, 82 (6): 2026-37. [PMID:3264290]
5. Goldring MB, Krane SM. (1987) Modulation by recombinant interleukin 1 of synthesis of types I and III collagens and associated procollagen mRNA levels in cultured human cells. J Biol Chem, 262 (34): 16724-9. [PMID:3500170]
6. Lacy SE, Wu C, Ambrosi DJ, Hsieh CM, Bose S, Miller R, Conlon DM, Tarcsa E, Chari R, Ghayur T et al.. (2015) Generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-Ig(TM)) molecule that specifically and potently neutralizes both IL-1α and IL-1β. MAbs, 7 (3): 605-19. [PMID:25764208]
7. McGuire-Goldring MB, Meats JE, Wood DD, Ihrie EJ, Ebsworth NM, Russell RG. (1984) In vitro activation of human chondrocytes and synoviocytes by a human interleukin-1-like factor. Arthritis Rheum, 27 (6): 654-62. [PMID:6610426]
8. Wang SX, Abramson SB, Attur M, Karsdal MA, Preston RA, Lozada CJ, Kosloski MP, Hong F, Jiang P, Saltarelli MJ et al.. (2017) Safety, tolerability, and pharmacodynamics of an anti-interleukin-1α/β dual variable domain immunoglobulin in patients with osteoarthritis of the knee: a randomized phase 1 study. Osteoarthr Cartil, 25 (12): 1952-1961. [PMID:28964890]

References

1. Dayer JM, Graham R, Russell G, Krane SM. (1977)
Collagenase production by rheumatoid synovial cells: stimulation by a human lymphocyte factor.
Science, 195 (4274): 181-3. [PMID:188134]

2. Dayer JM, Roelke MS, Krane SM. (1984)
Effects of prostaglandin E2, indomethacin, trifluoperazine and drugs affecting the cytoskeleton on collagenase production by cultured adherent rheumatoid synovial cells.
Biochem Pharmacol, 33 (18): 2893-9. [PMID:6089839]

3. DiGiammarino E, Ghayur T, Liu J. (2012)
Design and generation of DVD-Ig™ molecules for dual-specific targeting.
Methods Mol Biol, 899: 145-56. [PMID:22735951]

4. Goldring MB, Birkhead J, Sandell LJ, Kimura T, Krane SM. (1988)
Interleukin 1 suppresses expression of cartilage-specific types II and IX collagens and increases types I and III collagens in human chondrocytes.
J Clin Invest, 82 (6): 2026-37. [PMID:3264290]

5. Goldring MB, Krane SM. (1987)
Modulation by recombinant interleukin 1 of synthesis of types I and III collagens and associated procollagen mRNA levels in cultured human cells.
J Biol Chem, 262 (34): 16724-9. [PMID:3500170]

6. Lacy SE, Wu C, Ambrosi DJ, Hsieh CM, Bose S, Miller R, Conlon DM, Tarcsa E, Chari R, Ghayur T et al.. (2015)
Generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-Ig(TM)) molecule that specifically and potently neutralizes both IL-1α and IL-1β.
MAbs, 7 (3): 605-19. [PMID:25764208]

7. McGuire-Goldring MB, Meats JE, Wood DD, Ihrie EJ, Ebsworth NM, Russell RG. (1984)
In vitro activation of human chondrocytes and synoviocytes by a human interleukin-1-like factor.
Arthritis Rheum, 27 (6): 654-62. [PMID:6610426]

8. Wang SX, Abramson SB, Attur M, Karsdal MA, Preston RA, Lozada CJ, Kosloski MP, Hong F, Jiang P, Saltarelli MJ et al.. (2017)
Safety, tolerability, and pharmacodynamics of an anti-interleukin-1α/β dual variable domain immunoglobulin in patients with osteoarthritis of the knee: a randomized phase 1 study.
Osteoarthr Cartil, 25 (12): 1952-1961. [PMID:28964890]