ipragliflozin

Ligand id: 9394

Name: ipragliflozin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 4
Rotatable bonds 4
Topological polar surface area 118.39
Molecular weight 404.11
XLogP 3.57
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Faillie JL. (2016)
Pharmacological aspects of the safety of gliflozins.
Pharmacol. Res.,  [Epub ahead of print]. [PMID:27389050]
2. Imamura M, Nakanishi K, Suzuki T, Ikegai K, Shiraki R, Ogiyama T, Murakami T, Kurosaki E, Noda A, Kobayashi Y et al.. (2012)
Discovery of Ipragliflozin (ASP1941): a novel C-glucoside with benzothiophene structure as a potent and selective sodium glucose co-transporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes mellitus.
Bioorg. Med. Chem.20 (10): 3263-79. [PMID:22507206]
3. Lu CH, Min KW, Chuang LM, Kokubo S, Yoshida S, Cha BS. (2016)
Efficacy, safety, and tolerability of ipragliflozin in Asian patients with type 2 diabetes mellitus and inadequate glycemic control with metformin: Results of a phase 3 randomized, placebo-controlled, double-blind, multicenter trial.
J Diabetes Investig7 (3): 366-73. [PMID:27330723]
4. Tahara A, Kurosaki E, Yokono M, Yamajuku D, Kihara R, Hayashizaki Y, Takasu T, Imamura M, Qun L, Tomiyama H et al.. (2012)
Pharmacological profile of ipragliflozin (ASP1941), a novel selective SGLT2 inhibitor, in vitro and in vivo.
Naunyn Schmiedebergs Arch. Pharmacol.385 (4): 423-36. [PMID:22139434]