AZ13102909

Ligand id: 9577

Name: AZ13102909

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 5
Rotatable bonds 12
Topological polar surface area 142.23
Molecular weight 543.3
XLogP 5.55
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

References
1. Hasan M, Yan N. (2016)
Therapeutic potential of targeting TBK1 in autoimmune diseases and interferonopathies.
Pharmacol. Res.111: 336-42. [PMID:27353409]
2. Vu HL, Aplin AE. (2014)
Targeting TBK1 inhibits migration and resistance to MEK inhibitors in mutant NRAS melanoma.
Mol. Cancer Res.12 (10): 1509-19. [PMID:24962318]