CC-220

Ligand id: 9618

Name: CC-220

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 88.18
Molecular weight 449.2
XLogP 1.54
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Bjorklund CC, Lu L, Kang J, Hagner PR, Havens CG, Amatangelo M, Wang M, Ren Y, Couto S, Breider M et al.. (2015)
Rate of CRL4(CRBN) substrate Ikaros and Aiolos degradation underlies differential activity of lenalidomide and pomalidomide in multiple myeloma cells by regulation of c-Myc and IRF4.
Blood Cancer J5: e354. [PMID:26430725]
2. Cai X, Qiao Y, Diao C, Xu X, Chen Y, Du S, Liu X, Liu N, Yu S, Chen D et al.. (2014)
Association between polymorphisms of the IKZF3 gene and systemic lupus erythematosus in a Chinese Han population.
PLoS ONE9 (10): e108661. [PMID:25271777]
3. Matyskiela ME, Zhang W, Man HW, Muller G, Khambatta G, Baculi F, Hickman M, LeBrun L, Pagarigan B, Carmel G et al.. (2017)
A Cereblon Modulator (CC-220) with Improved Degradation of Ikaros and Aiolos.
J. Med. Chem.,  [Epub ahead of print]. [PMID:28425720]