cediranib

Ligand id: 5664

Name: cediranib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 8
Topological polar surface area 72.5
Molecular weight 450.21
XLogP 4
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Large-scale screening data

DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1,3

Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action Affinity Units
KIT proto-oncogene receptor tyrosine kinase KIT(V559D) Hs Inhibitor Inhibition 9.6 pKd
KIT proto-oncogene receptor tyrosine kinase KIT(V559D,V654A) Hs Inhibitor Inhibition 9.5 pKd
KIT proto-oncogene receptor tyrosine kinase KIT(V559D,T670I) Hs Inhibitor Inhibition 9.5 pKd
platelet derived growth factor receptor beta PDGFRB Hs Inhibitor Inhibition 9.5 pKd
KIT proto-oncogene receptor tyrosine kinase KIT Hs Inhibitor Inhibition 9.4 pKd
platelet derived growth factor receptor alpha PDGFRA Hs Inhibitor Inhibition 9.4 pKd
KIT proto-oncogene receptor tyrosine kinase KIT(L576P) Hs Inhibitor Inhibition 9.3 pKd
fms related tyrosine kinase 1 FLT1 Hs Inhibitor Inhibition 9.1 pKd
kinase insert domain receptor VEGFR2 Hs Inhibitor Inhibition 9.0 pKd
discoidin domain receptor tyrosine kinase 1 DDR1 Hs Inhibitor Inhibition 8.8 pKd
Displaying the top 10 targets  View all targets in screen »